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KMID : 0613820110210030406
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Journal of Life Science
2011 Volume.21 No. 3 p.406 ~ p.411
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Effects of Short-Term Exposure with Tri-n-Butyltin Chloride (TBTCl) and Bisphenol A on the Reproduction of the Striped Field Mouse
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Kim Ji-Hye
Min Byung-Yoon
Yoon Myung-Hee
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Abstract
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To investigate the effects of short-term treatment with tri-n-butyltin chloride (TBTCl) and bisphenol A (BPA) on the reproduction of striped field mice, the mice were intramuscularly injected with TBTCl or BPA immediately before the reproductive season and examined in the reproductive season after keeping them for 4 months. As a result, there were no differences between the control and the compound-treated groups regarding body weight in both sexes, the residual levels of the compounds in the adult males, and the gonadosomatic index (GSI) and the histological structures with LM and EM of the testes and epididymides in both the adult and young males. The infant mortality and abortion rate, however, were high in the TBTCl-treated groups and BPA-treated groups respectively, compared to the control group. Conclusively, it was suggested that short-term treatment with TBTCl or BPA in mice in the non-reproductive season might have inhibited the development of the uterine embryos or fetuses, although it did not induce accumulations of these compounds or affect the reproductive organs of adult and young (F1) males.
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KEYWORD
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Bisphenol A, infant mortality, gonadosomatic index (GSI), reproductive organ, tri-n-butyltin chloride (TBTCl)
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